| Date | Location | Result | |
| 11/13/21 | Springfield, MO | Missouri S&T 3, Drury 1 (25-19,25-20,23-25,25-23) | Box score |
| 11/12/21 | Rolla, MO | Rockhurst 3, Missouri S&T 2 (25-17,23-25,25-16,23-25,15-9) | Box score |
| 11/09/21 | Bolivar, MO | Missouri S&T 3, Southwest Baptist 2 (20-25,25-16,25-20,21-25,15-12) | Box score |
| 11/06/21 | Kansas City, MO | Missouri S&T 3, Rockhurst 0 (25-23,25-20,25-16) | Box score |
| 11/05/21 | Liberty, MO | Missouri S&T 3, William Jewell 2 (21-25,25-19,22-25,25-22,15-10) | Box score |
| 10/30/21 | Indianapolis, IN | UIndy 3, Missouri S&T 0 (25-23,25-23,25-20) | Box score |
| 10/29/21 | Lebanon, IL | McKendree 3, Missouri S&T 2 (16-25,27-25,25-21,14-25,15-12) | Box score |
| 10/23/21 | Rolla, MO | Missouri S&T 3, Lindenwood (MO) 1 (25-17,25-16,22-25,25-18) | Box score |
| 10/22/21 | Rolla, MO | Missouri S&T 3, Maryville (MO) 0 (25-12,25-18,25-14) | Box score |
| 10/16/21 | Walsh 3, Missouri S&T 1 (15-25,25-23,25-20,25-16) | Box score | |
| 10/15/21 | Hammond, IN | Michigan Tech 3, Missouri S&T 2 (23-25,25-23,22-25,25-17,15-13) | Box score |
| 10/15/21 | Hammond, IN | Missouri S&T 3, Saginaw Valley 2 (25-20,25-23,13-25,22-25,15-13) | Box score |
| 10/09/21 | Rolla, MO | Lewis 3, Missouri S&T 0 (25-14,25-22,25-13) | Box score |
| 10/08/21 | Rolla, MO | Missouri S&T 3, Ill. Springfield 2 (25-23,25-20,23-25,21-25,15-10) | Box score |
| 10/05/21 | St. Louis, MO | Mo.-St. Louis 3, Missouri S&T 0 (25-22,25-12,25-13) | Box score |
| 10/02/21 | Rolla, MO | Missouri S&T 3, William Jewell 1 (25-16,25-14,21-25,28-26) | Box score |
| 10/01/21 | Rolla, MO | Missouri S&T 3, Southwest Baptist 0 (25-23,25-16,25-21) | Box score |
| 09/28/21 | Rolla, MO | Missouri S&T 3, Drury 1 (25-27,25-17,25-14,28-26) | Box score |
| 09/25/21 | Quincy, IL | Quincy 3, Missouri S&T 0 (25-20,25-18,25-21) | Box score |
| 09/24/21 | Kirksville, MO | Missouri S&T 3, Truman 0 (25-16,25-22,25-23) | Box score |
| 09/18/21 | Rolla, MO | Missouri S&T 3, Southern Ind. 2 (26-24,25-23,19-25,20-25,15-9) | Box score |
| 09/11/21 | Indianapolis, IN | Winona St. 3, Missouri S&T 0 (25-17,25-16,25-18) | Box score |
| 09/11/21 | Indianapolis, IN | Missouri S&T 3, UIndy 2 (28-26,14-25,13-25,25-23,15-10) | Box score |
| 09/10/21 | Indianapolis, IN | Missouri S&T 3, Bemidji St. 2 (18-25,25-20,25-10,22-25,15-11) | Box score |
| 09/10/21 | Indianapolis, IN | Missouri S&T 3, Wheeling 1 (25-19,20-25,25-22,25-23) | Box score |
| 09/04/21 | Rolla, MO | Missouri S&T 3, Missouri Western 1 (25-21,20-25,25-18,25-21) | Box score |
| 09/04/21 | Rolla, MO | Missouri S&T 3, Ark.-Monticello 0 (25-18,25-16,25-21) | Box score |
| 09/03/21 | Rolla, MO | Upper Iowa 3, Missouri S&T 2 (28-26,27-25,22-25,23-25,15-13) | Box score |
| 09/03/21 | Rolla, MO | Missouri S&T 3, Purdue Northwest 0 (26-24,25-14,25-9) | Box score |